To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors.
The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis.
Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm.
Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day.
Journal of Pakistan Medical Association
Kazi, S. G.,
Habib, M. I.,
Khan, K. A.,
(2016). Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit. Journal of Pakistan Medical Association, 66(8), 961-967.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_emerg_med/131