Lung function decrement with arsenic exposure to drinking groundwater along river Indus: A comparative cross-sectional study

Document Type



Community Health Sciences; Pulmonary and Critical Care


This study was designed to determine the association between chronic arsenic exposure through drinking groundwater and decrement in lung function, particularly among individuals who do not have signs of arsenic lesions, among an adult population. This was a comparative cross-sectional study conducted during the months of January to March 2009. One hundred participants a parts per thousand yen15 years of age in each group, i.e. exposed (a parts per thousand yen100 mu g/l) and unexposed (a parts per thousand currency sign10 mu g/l) to arsenic, determined by testing drinking water samples (using portable kits), were compared for effects on lung function using spirometry. A structured and validated questionnaire was administered. Examination for arsenic skin lesions was also done. There was a decline in the mean adjusted FEV1 of 154.3 ml (95% CI: -324.7, 16.0, p = 0.076), in mean adjusted FVC of 221.9 ml (95% CI: -419.5, -24.3, p = 0.028), and in FEV1/FVC ratio of 2.0 (95% CI: -25.3, 29.4, p = 0.884) among participants who were exposed to arsenic compared to those unexposed. A separate model comprising a total of 160 participants, 60 exposed to arsenic concentrations a parts per thousand yen250 mu g/l and 100 unexposed at arsenic concentrations of a parts per thousand currency sign10 mu g/l, showed a decrement in mean adjusted FEV1 of 226.4 ml (95% CI: -430.4, -22.4, p = 0.030), in mean adjusted FVC of 354.8 ml (95% CI: -583.6, -126.0, p = 0.003), and in FEV1/FVC ratio of 9.9 (95% CI: -21.8, 41.6, p = 0.539) among participants who were exposed to arsenic in drinking groundwater. This study demonstrated that decrement in lung function is associated with chronic exposure to arsenic in drinking groundwater, occurring independently, and even before any manifestation, of arsenic skin lesions or respiratory symptoms. The study also demonstrated a dose-response effect of arsenic exposure and lung function decrement.


Environmental Geochemistry and Health