Document Type
Article
Department
Community Health Sciences
Abstract
Background: Chronic airflow obstruction is a key characteristic of chronic obstructive pulmonary disease. We investigated whether isolated small airways obstruction is associated with chronic airflow obstruction later in life.
Methods: We used longitudinal data from 3957 participants of the multinational Burden of Obstructive Lung Disease study. We defined isolated small airways obstruction using the prebronchodilator mean forced expiratory flow rate between 25% and 75% of the forced vital capacity (FVC) (FEF25-75) if a result was less than the lower limit of normal.
Results: Median follow-up time was 8.3 years. Chronic airflow obstruction was more likely to develop in participants with isolated small airways obstruction at baseline (FEF25-75 less than the LLN, OR: 2.95, 95% CI 1.02 to 8.54; FEV3/FVC less than the LLN, OR: 1.94, 95% CI 1.05 to 3.62). FEF25-75 was better than the FEV3/FVC ratio to discriminate future chronic airflow obstruction (AUC: 0.764 vs 0.692). Results were similar among participants of the UK Biobank study.
Conclusion: Measurements of small airways obstruction can be used as early markers of future obstructive lung disease.
Publication (Name of Journal)
BMJ Open Respiratory Research
DOI
http://dx.doi.org/10.1136/bmjresp-2023-002056
Recommended Citation
Brown, B. K.,
Potts, J.,
Santofimio, V. Q.,
Minelli, C.,
Patel, J.,
Burney, P. G.,
Amaral, A. F.,
Abass, N. M.,
Agarwal, D.,
Nafees, A.
(2023). Isolated small airways obstruction predicts future chronic airflow obstruction: A multinational longitudinal study. BMJ Open Respiratory Research, 10(1).
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs/1104
Comments
Pagination is not provided by the author/publisher.