Evaluation of MONOFER-induced hypersensitive reactions: A retrospective cohort study
Biological and Biomedical Sciences; Medicine; Internal Medicine
Iron deficiency is the most common cause of anaemia. Over the years, various IV preparations of iron have been developed, including Monofer® (Iron isomaltoside 1000), that showed a remarkable reduction in the occurance of hypersensitivity reactions. The main aim of the study was to evaluate the severity and extent to which hypersensitivity reactions occur after the administration of IV iron isomaltoside 1000 in an Asian population. Multistage sampling was adopted for this study. The overall sample size was 864. The mean age of the participants was 55.29 ±18.44 years. The results depicted that 63 (7.29%) of the entire participants faced hypersensitivity reactions after IV administration. A total of 43 (68.25%) participants who experienced hypersensitivity reactions showed clinical symptoms within one hour, 11(17.46%) showed reaction in 1-3 hours and 9 (14.29%) showed in > 3 Hours. The majority of the studied population showed significant improvement only after the administration of Pheniramine maleate, while only a few of them received Hydrocortisone.
Publication ( Name of Journal)
Journal of the Pakistan Medical Association
Ihsan, M. U.,
(2023). Evaluation of MONOFER-induced hypersensitive reactions: A retrospective cohort study. Journal of the Pakistan Medical Association, 73(1), 131-134.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/997