Biological and Biomedical Sciences
Objective: To investigate whether the time rate of change in heart rate i.e. cardiac acceleration, during aerobic exercise in human subjects could be used to differentiate vagal withdrawal from sympathetic stimulation.Methods: Fifteen male subjects exercised on a bicycle ergometer at 50 Watts (Step 1), then 100 Watts (Step 2), for 2 minutes each.Results: Heart rate (HR) was monitored from a resting value (mean +/- SD) of 80.3 +/- 12.9 to 113.8 +/- 13.6 beats min-1 in Step 1. In Step 2 exercise, HR increased from 113.8 +/- 13.6 to 145 +/- 20 beats min-1. At the initiation of Step 1, a rapid acceleration of HR was observed in the form of an overshoot response. In contrast to Step 1, a small overshoot response of cardiac acceleration was observed during Step 2. The difference between the mean cardiac acceleration at 10 seconds in Steps 1 and 2 was significant (2.40 +/- 0.19 and 0.71 +/- 0.12 beats min-1 sec-1, p < 0.0001).CONCLUSION: The initial vagal withdrawal of exercise-induced tachycardia, as a frontline adaptive mechanism, can be indirectly identified from HR transients using cardiac acceleration as a new marker.
Journal of Pakistan Medical Association
Bokhari, S. S.,
Ahmad, H. R.,
Subhan, M. M.,
Ali, S. A.,
Khan, M. N.
(2003). Cardiac acceleration as a marker of vagal withdrawal in heart rate control during exercise in humans. Journal of Pakistan Medical Association, 53(8), 375-378.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/718