Protective effect of Artemisia scoparia extract against acetaminophen-induced hepatotoxicity
Biological and Biomedical Sciences
1. Hepatoprotective activity of hydro-methanolic extract of Artemisia scoparia (Compositae) was investigated against acetaminophen-induced hepatic damage. 2. Acetaminophen at a dose of 1 g/kg produced 100% mortality in mice while pretreatment of animals with plant extract (150 mg/kg) reduced the death rate to 20%. 3. Acetaminophen at a dose of 640 mg/kg produced liver damage in rats as manifested by the rise in serum levels of GOT and GPT to 1528 +/- 310 and 904 +/- 261 IU/l (n = 10) respectively, compared to respective control values of 80 +/- 11 and 38 +/- 09. 4. Pretreatment of rats with plant extract (150 mg/kg) lowered significantly the respective serum GOT and GPT levels to 85 +/- 11 and 23 +/- 06. 5. These results indicate that Artemisia scoparia contains hepatoprotective constituents and this study rationalizes the traditional use of this plant in hepatobiliary disorders.
Gilani, A. H.,
Janbaz, K. H.
(1993). Protective effect of Artemisia scoparia extract against acetaminophen-induced hepatotoxicity. General Pharmacology, 24(6), 1455-1458.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/617