Hypotensive action of coumarin glycosides from Daucus carota
Biological and Biomedical Sciences
Daucus carota (carrot) has been used in traditional medicine to treat hypertension. Activity-directed fractionation of aerial parts of D. carota resulted in the isolation of two cumarin glycosides coded as DC-2 and DC-3. Intravenous administration of these compounds caused a dose-dependent (1-10 mg/kg) fall in arterial blood pressure in normotensive anaesthetised rats. In the in vitro studies, both compounds caused a dose-dependent (10-200 microg/ml) inhibitory effect on spontaneously beating guinea pig atria as well as on the K+ -induced contractions of rabbit aorta at similar concentrations. These results indicate that DC-2 and DC-3 may be acting through blockade of calcium channels and this effect may be responsible for the blood pressure lowering effect of the compounds observed in the in vivo studies.
Publication ( Name of Journal)
Gilani, A. H.,
Saeed, S. A.,
(2000). Hypotensive action of coumarin glycosides from Daucus carota. Phytomedicine, 7(5), 423-426.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/513