Title

Effect of dehydration on the disposition kinetics of erythromycin in rabbits

Document Type

Article

Department

Biological and Biomedical Sciences

Abstract

The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.

Publication

Biopharmaceutics and Drug Disposition

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