Effect of dehydration on the disposition kinetics of erythromycin in rabbits
Biological and Biomedical Sciences
The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.
Biopharmaceutics and Drug Disposition
Niazi, S. K.,
Muzaffar, N. A.,
(1992). Effect of dehydration on the disposition kinetics of erythromycin in rabbits. Biopharmaceutics and Drug Disposition, 13(2), 77-82.
Available at: https://ecommons.aku.edu/pakistan_fhs_mc_bbs/461