Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF (IC50:4 and 6 microM respectively) than collagen (IC50: 132 microM). The in vivo experiments in rabbits showed that clove oil (50-100 mg/kg) afforded 100% protection against PAF (11 mg/kg, i.v.) and 70% protection against AA (2.0 mg/kg, i.v.)-induced thrombosis and shock due to pulmonary platelet thrombosis. It also inhibited thromboxane-A2 and 12-HETE production by human platelets incubated with [C14] AA. These results are indicative that clove oil is inhibitory of platelet aggregation and thromboxane synthesis and may act as anti-thrombotic agent.
Publication (Name of Journal)
Journal of Pakistan Medical Association
Recommended Citation
Saeed, S. A.,
Gilani, A. H.
(1994). Antithrombotic activity of clove oil. Journal of Pakistan Medical Association, 44(5), 112-115.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/400