Novel Chemotherapeutic Strategies in the Management of Primary Amoebic Meningoencephalitis Due to Naegleria fowleri

Document Type

Letter to the Editor


Biological and Biomedical Sciences


Primary amoebic meningoencephalitis (PAM) due to Naegleria fowleri is a fulminating infection that can result in death within days. The disease prognosis is poor, although early diagnosis and aggressive treatment might increase survival chances [1]. Through contaminated water, N. fowleri enters nostrils and then migrates along the olfactory nerve, through the cribriform plate into the brain [2]. PAM is characterized by parosmia, rapidly progressing to anosmia (with resultant ageusia) as the nerve cells of the olfactory bulbs are destroyed leading to seizures and finally death [3].

Publication (Name of Journal)

CNS Neuroscience & Therapeutics