Recommendations for the management of Acanthamoeba keratitis

Document Type

News Article


Biological and Biomedical Sciences


Acanthamoeba is the causative agent of a painful, sight-threatening keratitis. The first case of Acanthamoeba keratitis was reported in 1972 in the USA and soon after, it was reported in the UK in 1974 (Nagington et al., 1974). Ulcerative keratitis due to Acanthamoeba is often associated with the improper use of contact lenses, but it is also reported in non-contact lens wearers (Sharma et al., 2000). At present, treatment involves hourly topical application of a mixture of anti-Acanthamoeba drugs including 0.02 % polyhexamethylene biguanide or chlorhexidine for up to a week. The hourly drops may be reduced after 48 h to alleviate the epithelial toxicity, but treatment continues for up to a year (Clarke et al., 2012).

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