FACTORS ASSOCIATED WITH ANTIRETROVIRAL DRUG RESISTANCE MUTATIONS AMONG PLHIV FAILING TO ACHIEVE VIROLOGICAL SUPPRESSION ON SECOND LINE TREATMENT IN TANZANIA.

Author

MABULA M. MABELELE

Date of Award

2024

Degree Type

Dissertation

Degree Name

Master of Medicine (MMed)

First Advisor

Dr. Fatma Bakshi

Second Advisor

Dr. Samina Somji

Third Advisor

Dr. Philip Adebayo

Department

Internal Medicine

Abstract

v> Human Immunodeficiency Virus / Acquired Immunodeficiency Syndrome (HIV/AIDS) is a major public health problem affecting an estimated 38.4 million people globally, with the (54%) of them being from the Eastern and Southern African regions. Despite progress in the availability of multiple classes of antiretroviral drugs and early initiation of treatment with cART, many patients still fail therapy in the first and second-line regimens due to drug resistance driven by continuous acquisition of drug resistance mutation (DRMs). DRMs are high among adults failing treatment regimens, ranging between 50-97%.

Recommended Citation

MABELELE, M. M. (2024). FACTORS ASSOCIATED WITH ANTIRETROVIRAL DRUG RESISTANCE MUTATIONS AMONG PLHIV FAILING TO ACHIEVE VIROLOGICAL SUPPRESSION ON SECOND LINE TREATMENT IN TANZANIA.. .
Available at: https://ecommons.aku.edu/etd_tz_mc_m-intmed/1