Title

The INTERGROWTH-21 st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children

Authors

Michelle Fernandes, Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United Kingdom
Alan Stein, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom
Charles R Newton, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom, KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
Leila Cheikh-Ismail, Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United Kingdom
Michael Kihara, Department of Psychology, United States International University, Nairobi, Kenya, KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
Katharina Wulff, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
Enrique de León Quintana, Centro de Tecnología e Innovación, Mexico City, Mexico
Luis Aranzeta, Centro de Tecnología e Innovación, Mexico City, Mexico
Aureli Soria-Frisch, Neuroscience Business Unit, Starlab Barcelona, SL, Barcelona, Spain
Javier Acedo, Neuroscience Business Unit, Starlab Barcelona, SL, Barcelona, Spain
David Ibanez, Neuroscience Business Unit, Starlab Barcelona, SL, Barcelona, Spain
Amina Abubakar, Aga Khan UniversityFollow
Francesca Giuliani, Dipartimento di Scienze Pediatriche e dell' Adolescenza, SCDU Neonatologia, Università di Torino, Turin, Italy
Tamsin Lewis, Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United Kingdom
Stephen Kennedy, Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United Kingdom
Jose Villar, Nuffield Department of Obstetrics & Gynaecology, and Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, United Kingdom

Document Type

Article

Department

Institute for Human Development

Abstract

Abstract: Background The International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) Project is a population-based, longitudinal study describing early growth and development in an optimally healthy cohort of 4607 mothers and newborns. At 24 months, children are assessed for neurodevelopmental outcomes with the INTERGROWTH-21st Neurodevelopment Package. This paper describes neurodevelopment tools for preschoolers and the systematic approach leading to the development of the Package.

Methods An advisory panel shortlisted project-specific criteria (such as multi-dimensional assessments and suitability for international populations) to be fulfilled by a neurodevelopment instrument. A literature review of well-established tools for preschoolers revealed 47 candidates, none of which fulfilled all the project's criteria. A multi-dimensional assessment was, therefore, compiled using a package-based approach by: (i) categorizing desired outcomes into domains, (ii) devising domain-specific criteria for tool selection, and (iii) selecting the most appropriate measure for each domain.

Results The Package measures vision (Cardiff tests); cortical auditory processing (auditory evoked potentials to a novelty oddball paradigm); and cognition, language skills, behavior, motor skills and attention (the INTERGROWTH-21st Neurodevelopment Assessment) in 35–45 minutes. Sleep-wake patterns (actigraphy) are also assessed. Tablet-based applications with integrated quality checks and automated, wireless electroencephalography make the Package easy to administer in the field by non-specialist staff. The Package is in use in Brazil, India, Italy, Kenya and the United Kingdom.

Conclusions The INTERGROWTH-21st Neurodevelopment Package is a multi-dimensional instrument measuring early child development (ECD). Its developmental approach may be useful to those involved in large-scale ECD research and surveillance efforts.

Comments

This work was published before the author joined Aga Khan University.

Publication

PloS one

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