Title

Sickle cell trait frequencies in blood donors and its effect among recepients in Bungoma County, Kenya

Document Type

Article

Department

Pathology (East Africa)

Abstract

Objective: This study aimed at evaluating the prevalence of sickle cell trait among the blood donors and its impact in transfused patients in Bungoma County. Design: A cross sectional study targeting healthy blood donors and patients transfused with sickle cell trait blood in Bungoma County from January 2019 to January 2020. Participants: A total of 350 blood donors and 10 patients transfused with sickle cell trait blood were enrolled. Results: The sickle cell trait prevalence amongst the blood donor population in Bungoma County was deduced to be 14.28%. White, red blood cell counts, haemoglobin, haematocrit, mean cell volume, mean cell haemoglobin and mean cell haemoglobin concentration parameters were not affected in patients transfused with sickle cell trait blood (p= 0.466, 0.980, 0.787, 0.886, 0.971, 0.476 and 0.524). Also, liver function tests in the same patients was not affected (p= 0.2193, 0.4678, 0.3052 and 0.7263) respectively for Alanine, Aspartate, Direct and Total Bilirubin levels respectively. Conclusion: There were no clinical abnormalities in patients transfused with sickle cell trait, however it was observed that acquired haemoglobin AS (Sickle cell trait) was detected among the transfused population.

Publication

East African Medical Journal

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