Title

Clear Cell Lesions of the Mullerian System: Not Always That "Clear"!

Document Type

Article

Department

Pathology (East Africa)

Abstract

A spectrum of lesions, benign and malignant, of the Mullerian system display clear cells. Interpretation of this finding can be confusing resulting in significant interobserver variability even among gynecologic pathologists.1 It is critical to distinguish bona fide clear cell carcinoma from other endometrial lesions as management is significantly different. We present some key morphologic aspects of endometrial clear cell carcinoma and compare it with 2 other endometrial lesions with clear cells: endometrial surface epithelial changes, clear cell type (SECs),2 and Arias- Stella reaction, posing a major diagnostic pitfall, especially when present in small biopsy material.

Publication

International Journal of Surgical Pathology

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