Fibroadenoma With Pleomorphic Stromal Giant Cells: It's Not as Bad as It Looks!
Pathology (East Africa)
Clinically relevant histological categorization of fibroepithelial lesions can be a daunting task, especially in a core needle biopsy. Assessment of stromal nuclear atypia, including nuclear pleomorphism and mitotic activity, is a key morphological feature employed to classify fibroepithelial lesions. We describe a case of fibroadenoma with markedly atypical nuclear features in the stromal cells that led to misclassification as phyllodes tumor in the core needle biopsy. Excision showed a fibroadenoma containing pleomorphic stromal giant cells, with occasional mitotic figures, including atypical forms. Aforementioned nuclear findings in a fibroepithelial lesion raise a legitimate question of phyllodes tumor. Knowledge of this pitfall may help avoid overtreatment of an otherwise benign fibroepithelial lesion.
International Journal of Surgical Pathology
Steinhoff, M. M.
(2017). Fibroadenoma With Pleomorphic Stromal Giant Cells: It's Not as Bad as It Looks!. International Journal of Surgical Pathology, 25(5), 425-427.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_pathol/155