Elevated supar levels, organ dysfunction and death in children hospitalized with malaria: considerations for use as a risk stratification tool
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
Soluble urokinase-type plasminogen activator receptor (suPAR) is an emerging critical illness biomarker. Circulating suPAR levels are elevated in severe malaria and are associated with mortality. The present study evaluated clinical predictors of elevated plasma suPAR (≥15ng/mL). Elevated suPAR occurred in 22.1% of 1226 Ugandan children with severe malaria, and was independently associated with severe acute kidney injury, hyperlactatemia, and coma as well as biomarkers of immune and endothelial activation. An optimized clinical decision algorithm that prioritizes suPAR testing for children with clinical danger signs, including coma and kidney injury could improve the identification of children at highest risk of mortality.
Publication (Name of Journal)
The Journal of Infectious Diseases
DOI
https://doi.org/10.1093/infdis/jiaf327
Recommended Citation
Ssuuna, C.,
Mishra, H.,
T Hawkes, M.,
Stefanova, V.,
Leligdowicz, A.,
Lintner-Rivera, M.,
Batte, A.,
Zhong, K.,
Namasopo, S.,
Opoka, R.
(2025). Elevated supar levels, organ dysfunction and death in children hospitalized with malaria: considerations for use as a risk stratification tool. The Journal of Infectious Diseases, 1-9.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/584