Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia
Document Type
Article
Department
Paediatrics and Child Health (East Africa)
Abstract
Retrospective studies suggest that there is high mortality in children with sickle cell anemia (SCA) and severe malaria. We assessed mortality in Ugandan children with severe malarial anemia (SMA, n = 232) or cerebral malaria (CM, n = 267) by sickle cell hemoglobin genotype. Admission and 2-year follow-up mortality did not differ among children with SMA who had homozygous form of sickle cell hemoglobin (HbSS) versus normal form of adult hemoglobin (admission, 0/22, 0%, vs. 1/208, 0.5%; follow-up, 1/22, 4.5%; 7/207, 3.4%, respectively; all P > 0.6). The single child with CM and HbSS survived. The study findings highlight the need for large prospective studies of malaria-related mortality in children with SCA.
Publication (Name of Journal)
Pediatr Blood Cancer
DOI
10.1002/pbc.26745
Recommended Citation
Opoka, R.,
Bangirana, P.,
Idro, R.,
Shabani, E.,
Namazzi, R.,
John, C. C.
(2018). Lack of mortality in 22 children with sickle cell anemia and severe malarial anemia. Pediatr Blood Cancer, 65(1), 1-7.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/444
Comments
This work was published before the author joined Aga Khan University.