Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Authors

Michael Hawkes, University of Alberta
Andrea L. Conroy, University of Toronto
Robert Opoka, Aga Khan UniversityFollow
Sophie Namasopo, Jinja Regional Referral Hospital
Kathleen Zhong, University Health Network–Toronto General Hospital
W. Conrad Liles, University of Washington
Chandy C. John, University of Minnesota
Kevin C. Kain, Sandra Rotman Centre for Global Health

Document Type

Article

Department

Paediatrics and Child Health (East Africa)

Abstract

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Emerging infectious diseases

DOI

10.3201/eid2107.150213

Recommended Citation

Hawkes, M., Conroy, A. L., Opoka, R., Namasopo, S., Zhong, K., Liles, W. C., John, C. C., Kain, K. C. (2015). Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.. Emerging infectious diseases, 21(7), 1237-1239.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/382