Title

Intrathecal Baclofen and Spasticity: What Do We Know and What Do We Need to Know?

Document Type

Article

Department

Paediatrics and Child Health (East Africa)

Abstract

BACLOFEN (B-[4-chlorophenyl -GABA; Lioresal) is a synthetic gamma-aminobutyric-acid (GABA) agonist which acts selectively on GABA-B receptors. Baclofen has an inhibitory effect on presynaptic transmitter release by restricting calcium influx into presynaptic terminals'. It appears also to act at postsynaptic terminals, with depression of neuronal activity by increasing potassium conductance2. GABA-B receptors are concentrated in layers II and III of the dorsal grey matter of the spinal cord and at various other sites in the central nervous system, especially the thalamus'.

Publication

Developmental Medicine and Child Neurology

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