Endothelial activation, acute kidney injury, and cognitive impairment in pediatric severe malaria

Benson Ouma, Makerere University, Uganda.
John Ssenkusu, Makerere University, Uganda
Estela Shabani, Indiana University, USA
Dibyadyuti Datta, Indiana University, USA
Robert Opoka, Aga Khan University
Richard Idro, Makerere University, Uganda
Paul Bangirana, Makerere University, Uganda
Gregory Park Park, University of Minnesota, Mineapolis

This work was published before the author joined Aga Khan University.


Objectives: Evaluate the relationship between endothelial activation, malaria complications, and long-term cognitive outcomes in severe malaria survivors. Design: Prospectively cohort study of children with cerebral malaria, severe malarial anemia, or community children.

Setting: Mulago National Referral Hospital in Kampala, Uganda.

Subjects: Children 18 months to 12 years old with severe malaria (cerebral malaria, n = 253 or severe malarial anemia, n = 211) or community children (n = 206) were followed for 24 months. Interventions: None.