Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia

Authors

G Garbano, University Of Alabama At Birmingham, USA
Mansoor Saleh, Aga Khan UniversityFollow
P G. Mori, University Of Alabama At Birmingham, USA
A F. LoBuglio, University Of Alabama At Birmingham, USA
D Shaw, University Of Alabama At Birmingham, USA

Document Type

Article

Department

Haematology and Oncology, East Africa

Abstract

Ten patients with idiopathic thrombocytopenic purpura (ITP) were studied before and following a rise in circulating platelets subsequent to infusions of intravenous gammaglobulin (400 mg/kg/day x 5 days). We quantitated the amount of circulating IgG capable of binding to normal donor platelets in vitro using an 125I-monoclonal anti-human IgG assay, as well as the amount of IgG associated with the patients' platelets before and following therapy. We found no evidence for a decrease in platelet-specific IgG antibodies in these patients undergoing an acute response to therapy. These data suggest that the short-term efficacy of intravenous gammaglobulin is due to effects other than a substantive reduction in platelet reactive antibodies, such as the alteration of IgG-coated platelet destruction.

Comments

This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

Blood

DOI

https://doi.org/10.1182/blood.V73.3.662.662

Recommended Citation

Garbano, G., Saleh, M., Mori, P. G., LoBuglio, A. F., Shaw, D. (1989). Effect of intravenous gammaglobulin on circulating and platelet-bound antibody in immune thrombocytopenia. Blood, 73(3), 662-665.
Available at: https://ecommons.aku.edu/eastafrica_fhs_mc_haematol_oncol/150