Monoclonal antibody therapy of cancer
Document Type
Article
Department
Haematology and Oncology, East Africa
Abstract
Inherent or acquired resistance of tumor cells to conventional chemotherapeutic drugs [ 1,2] and the toxicity associated with these reagents [3] has led to a search for new options for the treatment of malignant diseases. By virtue of their unique antigen specificity, monoclonal antibodies (MoAb) targeted at tumor-associated antigens have emerged as a potentially important tool in the battle against cancer. The accomplishments of Kohler and Milstein [4] paved the way for the large-scale production of monoclonal antibodies of defined specificity.
Publication (Name of Journal)
Critical Reviews in Oncology/Hematology
DOI
https://doi.org/10.1016/1040-8428(92)90093-6
Recommended Citation
LoBuglio, A.,
Saleh, M.
(1992). Monoclonal antibody therapy of cancer. Critical Reviews in Oncology/Hematology, 13(3), 271-282.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_haematol_oncol/134
Comments
This work was published before the author joined Aga Khan University.