Centre for Regenerative Medicine
Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.
International Journal of Clinical and Experimental Pathology
(2011). Role of leptin and its receptors in the pathogenesis of thyroid cancer. International Journal of Clinical and Experimental Pathology, 4(7), 637-643.
Available at: https://ecommons.aku.edu/crm/15