Cadmium: sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas

Document Type



Brain and Mind Institute


1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment.

2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate 14C-thymidine into DNA.

3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.


This work was published before the author joined Aga Khan University.

Publication (Name of Journal)

General Pharmacology: The Vascular System