Cadmium: sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas
Brain and Mind Institute
1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment.
2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate 14C-thymidine into DNA.
3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.
General Pharmacology: The Vascular System
Singhal, R. L.
(1976). Cadmium: sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas. General Pharmacology: The Vascular System, 7(6), 433-435.
Available at: https://ecommons.aku.edu/bmi/302