Title

Cadmium: sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas

Document Type

Article

Department

Brain and Mind Institute

Abstract

1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment.

2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate 14C-thymidine into DNA.

3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.

Comments

This work was published before the author joined Aga Khan University.

Publication

General Pharmacology: The Vascular System

Share

COinS