Document Type
Article
Department
Brain and Mind Institute
Abstract
A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture of Souroubea spp. vine and Platanus spp. Bark, was tested as a canine anxiolytic for thunderstorm noise-induced stress (noise aversion). The tablet contained five highly stable triterpenes and delivered 10 mg of the active ingredient betulinic acid (BA) for an intended 1 mg/kg dose in a 10 kg dog. BA in tablets was stable for 30 months in storage at 23 °C. Efficacy of the tablets in reducing anxiety in dogs was assessed in a blinded, placebo-controlled study by recording changes in blood cortisol levels and measures of behavioral activity in response to recorded intermittent thunder. Sixty beagles were assigned into groups receiving: placebo, 0.5×, 1×, 2×, and 4× dose, or the positive control (diazepam), for five days. Reduction in anxiety measures was partially dose-dependent and the 1× dose was effective in reducing inactivity time (p = 0.0111) or increased activity time (p = 0.0299) compared with placebo, indicating a decrease in anxiety response. Cortisol measures also showed a dose-dependent reduction in cortisol in dogs treated with the test tablet.
Publication (Name of Journal)
Molecules
Recommended Citation
Masic, A.,
Landsberg, G.,
Milgram, B.,
Merali, Z.,
Durst, T.,
Vindas, P. S.,
Garcia, M.,
Baker, J.,
Liu, R.,
Arnason, J.
(2021). Efficacy of Souroubea-Platanus Dietary Supplement Containing Triterpenes in Beagle Dogs Using a Thunderstorm Noise-Induced Model of Fear and Anxiety. Molecules, 26(7), 1-8.
Available at:
https://ecommons.aku.edu/bmi/30
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.