DIABETOGENIC EFFECTS OF CHRONIC ORAL CADMIUM ADMINISTRATION TO NEONATAL RATS
Brain and Mind Institute
1.Chronic exposure of neonatal rats to oral cadmium (Cd) (0.1 and 1.0 μg/g daily for 45 days) disturbed glucose homeostasis, as reflected by hyperglycaemia, reduced liver glycogen and enhanced gluconeogenic potential of hepatic tissue.
2.This Cd-exposure regimen also increased hepatic cyclic adenosine 3′,5′-monophosphate (cyclic AMP) which was accompanied by enhancement of basal, adrenaline and glucagon-stimulated form(s) of adenylate cyclase.
3.In order to assess the responsiveness of pancreatic beta cells to glucose, islets isolated from control as well as Cd-exposed animals were incubated in vitro and their rate of insulin secretion determined. In the presence of glucose 0.5 mg/ml, there was no significant difference in the rate of insulin release. However, at higher glucose concentrations (1.5 and 3.0 mg/ml), the islets from Cd-exposed rats released significantly less insulin than those of control animals.
4.The results are discussed in relation to the possible mechanism of the diabetogenic effect of Cd.
Publication ( Name of Journal)
British Journal of Pharmacology
SINGHAL, R. L.
(1980). DIABETOGENIC EFFECTS OF CHRONIC ORAL CADMIUM ADMINISTRATION TO NEONATAL RATS. British Journal of Pharmacology, 69(1), 151-157.
Available at: https://ecommons.aku.edu/bmi/297