Title

Role of Micro RNA-21 in Atherosclerosis

Document Type

Article

Department

Internal Medicine (East Africa); Brain and Mind Institute

Abstract

Micro RNAs (miR) are short non-coding RNAs that regulate several genes under pathophysiological conditions. Accumulating evidence suggest the involvement of miR in atherogenesis. However, limited information is available about atherogenic miR and the underling mechanisms by which miR affect atherogenesis. Our data shows that 12 weeks of western diet (WD) in LDL receptor-knockout (LDLR-KO) mice upregulated 99 and downregulated 50 miR in the aorta. Among the 41 differentially expressed miR associated with macrophage inflammation and apoptosis, expression of micro RNA-21 (miR-21) was increased by 1.4-fold (P

Comments

This work was published before the author joined Aga Khan University.

Publication

Arteriosclerosis, Thrombosis, and Vascular Biology

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