Stiff person syndrome (SPS) is a rare neurological disorder characterized by progressive muscle stiffness and rigidity, mostly involving axial muscles, resulting in functional disability. It is associated with elevated anti- Glutamic acid decarboxylase (GAD) antibody levels. Electromyography findings are often diagnostic. We present a case of a 48 years old male, who presented with progressive stiffness and rigidity of axial muscles and limbs. His EMG was consistent with SPS. Anti GAD antibodies were markedly elevated. He was treated with rituximab and has improved significantly. SPS is a difficult diagnosis, usually under diagnosed due to lack of awareness among medical community. There is a dire need to further study the disease and invent better treatment options for patients suffering from SPS.
Sajjad, Zoya; Abrar, Anam; Ullah, Zafar; Rehman, Aasim; Tariq, Wasim; and Ahmad, Arsalan
"Stiff person syndrome: a diagnostic and management challenge,"
Pakistan Journal of Neurological Sciences (PJNS): Vol. 9
, Article 11.
Available at: http://ecommons.aku.edu/pjns/vol9/iss4/11