To assess the efficacy of memantine as a preventive and therapeutic intervention for migraine and tension type headache. Material and Methods: This quasi experimental (pre and post experimental) was conducted for a period of 6 months. Patients were selected from a private tertiary care hospital setup a total of 44 patients receiving memantine, were selected through purposive sampling technique. Data was analysed using SPSS version 16.0 and associations were made using Chi square test with P value of less than 0.005 was taken as significant. Results: Out of 44 patients 35 (79.9%) were female and 9 (20.5%) were male which shows a very high occurrence of migraine and tension type headaches in females. Average age was found to be 32.6% Efficacy of the drug was observed to be 81.8% which is significantly high. The baseline MIDAS score when compared with score at 3 months follow up by applying Wilcoxon signed rank test showed mean ± S.D (39.52±21.27 vs. 6.72±6.41) where p=0.000 ≤0.005 which shows highly significant results. All 44 patients were known cases of migraine while 25% of them also suffered from tension type headache. Patients were treated on 10 mg dose of memantinea and were observed for the efficacy of the drug. Patients maintained their diaries of intensity of pain, distressing influence of pain and how it hindered their daily routine. Results show that intensity of pain fell significantly by the end of 3rd month of treatment while majority of the patients felt less distressed on their final follow up. By the end of the 3rd month the level of hindrance caused by the migraine pain in the daily routines of the patients also fell significantly. Conclusion: Memantine is effective as a preventive and therapeutic intervention for migraine and tension type headache
Sattar, Sidra and Soomro, Bashir
"Efficacy of memantine as a preventive and therapeutic intervention for migraine and tension type headache,"
Pakistan Journal of Neurological Sciences (PJNS): Vol. 10
, Article 5.
Available at: http://ecommons.aku.edu/pjns/vol10/iss4/5