Title

Metastasis on bone scan with low prostate specific antigen (≤20 ng/ml) and Gleason's score (<8) in newly diagnosed Pakistani males with prostate cancer: should we follow Western guidelines?

Document Type

Article

Department

Radiology

Abstract

Aim:To find out diagnostic correlation of prostate specific antigen (PSA) and Gleason' s score (GS) with bone metastasis (BM) in newly diagnosed prostate cancer (PC) Patients in Pakistan. Materials and

Methods:

This retrospective study included 204 newly diagnosed PC Patients who were referred for BS for staging.

Results:

The mean age, mean PSA and incidence of BM on BS were 7109 years, 111.058.5 ng/ml and 67/204 (33%), respectively. The mean GS of the studied population was 71. According to PSA levels, Patients were divided into 5 groups: /ml (77/204), >10-≤20 ng/ml (4/204), >20-≤50 ng/ml (22/204), >50-≤100 (25/204) and >100 ng/ml (38/204). The incidence of positive BS (%) for BM and mean GS (score SD) for each group were 14%, 71, 10%, 61, 32%, 71, 56%, 8∓1 and 82%, 81 respectively (significant p value). PSA and GS were statistically significant predictors of BM on BS and their predictive value was additive (p6 was more sensitive (88.9%) and less specific (56.2%) for diagnosing BM. Conclusions: (1) There is an overall increased incidence of BM in newly diagnosed Patients with PC and even at serum PSA level≤20 ng/ml and GS

Publication

Asian Pacific Journal of Cancer Prevention : Apjcp