Title

Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones

Document Type

Article

Department

Pathology and Microbiology

Abstract

Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.

Publication

Biochemical Journal