Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones
Pathology and Microbiology
Addition of alkyl ketone (10mM) to Gunn-rat liver homogenates increased UDP-glucuronyltransferase activity towards 2-aminophenol by 10--20 fold, up to enhanced values of enzyme activity observed with similarly treated Wistar-rat liver homogenates. Alkyl ketones also activate the defective enzyme purified from Gunn-rat liver. This genetic deficiency of UDP-glucuronyltransferase activity is no longer apparent when assayed in the presence of alkyl ketones.
(1979). Stimulation of defective Gunn-rat Liver Uridine diphosphate Glucuronyltransferase activity in vitro by Alkyl ketones. Biochemical Journal, 177(3), 993-995.
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