Probable Chromosomal Mutation to resistance to all Aminoglycosides in Staphylococcus Aureus selected by the Therapeutic use of Gentamicin: a preliminary report
Pathology and Microbiology
A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.
Journal of Antimicrobial Chemotherapy
A, S. J.,
W, L. R.
(1986). Probable Chromosomal Mutation to resistance to all Aminoglycosides in Staphylococcus Aureus selected by the Therapeutic use of Gentamicin: a preliminary report. Journal of Antimicrobial Chemotherapy, 17(5), 571-574.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/427