Pathology and Microbiology
Objective: To observe the frequency of histological subtypes of childhood non-Hodgkin`s lymphoma and its immunohistochemical profile.
Setting: All cases of non-Hodgkin’s lymphoma diagnosed in children (<15 years) in the section of histopithology at the Aga Khan University Hospital Karachi during the period of three years.
Methods: These consecutive cases were evaluated on H&E stained sections and then immunohistochemistry analysis of these tumors was performed by employing Peroxidase Anti-Peroxidase (PAP) technique.
Results: The present series included 61 cases of non-Hodgkin’s lymphoma. NHL was more common in males as compared to females with male to female ratio of 5.8:1. High grade NHL comprised 87% of childhood lymphoma. The mode of presentation in majority of NHL (57%) was extranodal. Burkitt’s lymphonia (33%) was the most prevalent histological subtypes, followed by lymphoblastic (28%), diffuse large cell (15%), diffuse mix small and large cell (13%), small non cleaved Non-Burkitts (7%) and immunoblastic (4%). Immunophenotypic analysis of the childhood Non-Hodgkin’s lymphoma revealed that 67% of the Non-Hodgkin’s Iy mphoma are cell type while 33% are those of T-cell lineage.
Conclusion: NHL was more common in males. Majority of NHL in children were high grade tumors. Burkitt’s lymphoma was the most frequent histological subtype. T-cell NUL comprised a significant portion of childhood lymphomas
Journal of Pakistan Medical Association
Shah, S. H.,
Hassan, S. H.
(2000). Childhood non-Hodgkin's Lymphoma: An immunophenotypic analysis.. Journal of Pakistan Medical Association, 50(3), 89-91.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/291