Ethambutol-induced optic neuritis and multiple sclerosis: Is there an association?
Although the development of multiple sclerosis (MS) after idiopathic optic neuritis (ON) is well known, MS following ethambutol-induced ON is not widely recognized. We hypothesize the possible association between ethambutol-induced ON and MS based on empirical data of six Patients with ethambutol-induced ON who progressed to MS. Whether there is a genuine link between ethambutol-induced ON and MS is unresolved, but our observations do raise the possibility. It is difficult to speculate on the mechanism for such a link, because the etiology of MS itself is unknown. It is possible that ethambutol or its metabolites induce an autoimmune response, through molecular mimicry or other phenomena, cross-reacting with central nervous system (CNS) myelin.
(2010). Ethambutol-induced optic neuritis and multiple sclerosis: Is there an association?. Medical Hypotheses, 75(6), 679-680.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_med_neurol/53