Evidence of segment reassortment in crimean-congo haemorrhagic fever virus
Medicine; Pathology and Microbiology
The complete nucleotide sequences of the small (S) and medium (M) segments of three independent strains of Crimean-Congo haemorrhagic fever (CCHF) virus isolated in Uzbekistan, Iraq and Pakistan have been determined. Partial S and M segment sequences from two additional strains and partial large segment sequences from five strains of CCHF virus have also been obtained. These data have been compiled and compared with published full-length and partial sequences of other CCHF virus strains. Analysis of virus strains for which complete and partial S and M segment sequences are available reveals that the phylogenetic grouping of some strains differ between these two segments. Data provided in this report suggest that this discrepancy is not the result of recombination, but rather the consequence of reassortment events that have occurred in some virus lineages. Although described in other genera of the Bunyaviridae family, this is the first report of segment reassortment occurring in the Nairovirus genus.
Journal of General Virology
(2004). Evidence of segment reassortment in crimean-congo haemorrhagic fever virus. Journal of General Virology, 85, 3059-3070.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_med_med/464