Title

Clinical factors associated with mortality in dengue infection at a tertiary care center

Document Type

Article

Department

Medicine

Abstract

We conducted a cross-sectional study to investigate the clinical factors associated with mortality in Patients with dengue viral infection at a tertiary care center over a 3 year period. Six hundred ninety-nine Patients with a clinical diagnosis of dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) during the study period were included in the study. Data were collected with a predesigned form comprised of demographics, duration of fever, associated symptoms, diagnosis of DF, DHF and DSS, and laboratory parameters [complete blood count, coagulation tests, creatinine, serum glutamic pyruvic transaminase (SGPT)], dengue IgM was checked in all Patients by ELISA Outcomes (survival/mortality) and complications were recorded. Mortality was the primaryoutcome measure. DF constituted 86 4% (604), DHF constituted 11.6% (81) and DSS constituted 2% (14) of Patients. The mortality rate was 2 7% (19). The mean white blood cell count in those who died was 13 3, in those who survived was 5.3, the difference was significant (p=0 02) The mean BUN in those who died was 33 2, those who survived was 13.8, (p=0.007). The mean bicarbonate level in those who died was 17 1, those who survived was 185 (p 300 mg/dl, bleeding, an altered mental status and shock at presentation were all significantly associated with mortality in Patients with dengue virus infection (p=0 008, p001, p001, p001, respectively)

Publication

Southeast Asian Journal of Tropical Medicine and Public Health