Seroprevalence of hepatitis E and Helicobacter pylori in a low socioeconomic area of a metropolitan city in a developing country
Document Type
Article
Department
Medicine; Gastroenterology
Abstract
This study aims to determine the prevalence of coinfection of H. pylori and hepatitis E virus (HEV) in the paediatric age group in an urban slum area of Karachi and identify risk factors associated with co-infection. Five hundred and forty children aged one to 15 years were investigated. Blood samples were collected and questionnaires completed on socio-demographic characteristics. Anti-H. pylori, HEV IgG and IgM antibodies were analysed by enzyme immunoassays (EIAs). Theseroprevalence of H. pylori antibody was 47.2%, while that of HEV IgG and IgM was 14.4% and 2.4%, respectively. 12.4% exhibited seroprevalence for both H. pylori and HEV (IgG). In 67 (26%) cases positive for H. pylori IgG, HEV IgG positivity was also seen (P<0.001). Only 13 (5%) positive for H. pylori were also positive for HEV IgM (P<0.001). Only 11 (4%) HEV IgG-positive cases were H. pylori antibody-negative (P<0.001). Hepatitis E virus was common in children who had access to municipal piped water (P=0.025). H. pylori was common in children who used a non-flush toilet system (P<0.001). Children exposed to H. pylori infection were also exposed to the risk of HEV.
Publication (Name of Journal)
British Journal of Biomedical Science
Recommended Citation
Jafri, W.,
Yakoob, J.,
Abid, S.,
Awan, S.,
Siddiqui, S.,
Jafri, F.,
Hamid, S.,
Nizami, S. Q.
(2013). Seroprevalence of hepatitis E and Helicobacter pylori in a low socioeconomic area of a metropolitan city in a developing country. British Journal of Biomedical Science, 70(i), 27-30.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_med_gastroenterol/41