Title

Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms

Document Type

Article

Department

Gastroenterology

Abstract

Background:Iron deficiency anaemia (IDA) due to occult gastrointestinal (GI) blood loss usually remains unnoticed until Patient become symptomatic. There is sparse data in IDA Patients without gastrointestinal symptoms. This study was designed to find out the frequency and predictors of endoscopic lesions in IDA without gastrointestinal symptoms. Cross-sectional study performed on a convenience sample of consecutive subjects.

Methods:

Ninety five consecutive Patients with laboratory based diagnosis of IDA having no gastrointestinal symptoms were interviewed and their clinical and biochemical variables were recorded. All the study Patients underwent esophago-gastroduodenoscopy (EGD) and colonoscopy. Endoscopic findings were documented as presence/absence of bleeding related lesion and presence/absence of cause of IDA. Multiple logistic regressions were performed to identify variables significantly related to outcome variables.

Results:

Possible cause of anaemia was found in 71% and bleeding related lesions were found in 53% of Patients. Upper gastrointestinal tract lesions were found in 41% of Patients with bleeding related lesions. On multivariable logistic regression, advancing age, low mean corpuscular volume (MCV Conclusion: Clinical and Biochemical markers can predict gastrointestinal lesions on endoscopy in IDA Patients without gastrointestinal symptoms. High proportion of upper gastrointestinal involvement warrants EGD as initial endoscopic procedure however, this needs validation by further studies.

Publication

BMC Gastroenterology