Effect of Low vs. High Dietary Sodium on Blood Pressure Levels in a Normotensive Indo-Asian Population
Document Type
Article
Department
Community Health Sciences
Abstract
Background: Hypertension is a major modifiable risk factor, and while sodium restriction in hypertensive Patients appears effective, its role in normotensive individuals remains unclear. We assessed the effect of a low vs. high-sodium diet on blood pressure in normotensive Indo-Asian adults. Methods: A randomized, controlled, crossover trial was conducted on 200 normotensive subjects randomly selected from the general population in Karachi, Pakistan. Participants were randomized to either a low (20 mEq/day) or a high-sodium diet (220 mEq/day) for 1 week, followed by 1 week of washout, then the alternate diet for I week. The primary outcome was difference in systolic blood pressure (SBP) measured at the end of each phase in the overall population. Results: Mean (95% confidence interval) decline in 24-h urinary sodium excretion was 81.0 (69.6-92.4) mEq/day (P < 0.001), and in SBP was 1 (0-3) mm Hg (P= 0.17) between high and low-sodium phase. A significant interaction was detected (P=0.001) between dietary sodium and baseline SBP with a greater adjusted mean (95% confidence interval) decline in SBP (6 (2-9) mm Hg) among participants with high-normal SBP (130-139 mm Hg) and no significant change (-1 (-2 to 1)) in those with normal baseline SBP (
Publication (Name of Journal)
American Journal of Hypertension
Recommended Citation
Jessani, S.,
Hatcher, J.,
Chaturvedi, N.,
Jafar, T.
(2008). Effect of Low vs. High Dietary Sodium on Blood Pressure Levels in a Normotensive Indo-Asian Population. American Journal of Hypertension, 21(11), 1238-1244.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_chs_chs/64