Hepatitis C therapy-the future looks bright
Biological and Biomedical Sciences
Hepatitis C virus (HCV) infections affect about 170 million individuals worldwide and can be life-threatening if left untreated. Over the past three decades, ribavirin and interferon-alpha have remained the only available medicines for treating hepatitis C sufferers. Given that this combination therapy is partially effective at best and is associated with severe side-effects, there is an unmet need for new molecular entities which inhibit HCV replication. By employing a combination of structure-based drug design together with high-throughput screening approaches, several pharmaceutical companies have been successful in identifying potentially useful compounds for treating HCV infections. This article provides an overview of some of the small-molecule inhibitors that have shown promise so far in clinical trials and which could reach the clinic within the next three years.
European Journal of Clinical Microbiology & Infectious Diseases
(2009). Hepatitis C therapy-the future looks bright. European Journal of Clinical Microbiology & Infectious Diseases, 28(12), 1409-1413.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_bbs/84