Antihypertensive, antioxidant, antidyslipidemic and endothelial modulating activities of a polyherbal formulation (POL-10)
Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
The present investigation was aimed at providing the pharmacological basis for the medicinal use of a polyherbal formulation (POL-10) in hypertension and dyslipidemia. In spontaneously hypertensive rats, POL-10 significantly (p < 0.05) reduced blood pressure to 183.2 +/- 2.97 vs 198.1 +/- 5.2 mmHg (Mean +/- S.E.M, n = 7-10), improved endothelial dysfunction (p < 0.01) by increasing acetylcholine-induced relaxation up to 46.0 +/- 6.7% vs 24.6 +/- 3.8% (n=5-10) and decreased serum triglycerides (TG) to 54.5 +/- 3.3 vs. 93.84 +/- 5.7 mg/dl (p < 0.001). In high fat diet-induced hypercholesterolemia, POL-10 caused reduction in total cholesterol (TC) low density lipoproteins (LDL) levels and the atherogic index (TC-HDL/HDL). It decreased TG levels in tyloxapol-induced hyperlipidemia and increased high-density lipoprotein cholesterol (HDL-C) and reduced atherogenic index in normotensive rats. it exhibited strong antioxidant activity in different in vitro assays. In isolated smooth muscle preparation, POL-10 exhibited calcium channel blocking (CCB) activity by inhibition of high K(+) induced contractions and rightward shift of Ca(++) concentration-response curves similar to that of verapamil. In conclusion, these findings rationalize the medicinal use of POL-10 in cardiovascular disorders which are mediated through multiple pathways such as, antioxidant, CCB, inhibition of lipid biosynthesis and absorption.
Publication (Name of Journal)
Vascular Pharmacology
Recommended Citation
Aziz, N.,
Mehmood, M.,
Mandukhal, S.,
Bashir, S.,
Raoof, S.,
Gilani, A.
(2009). Antihypertensive, antioxidant, antidyslipidemic and endothelial modulating activities of a polyherbal formulation (POL-10). Vascular Pharmacology, 50(2012-01-02), 57-64.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/29