Phenotypes of Alpha 1 Antitrypsin in Karachi, Pakistan
Document Type
Article
Department
Biological and Biomedical Sciences
Abstract
Objective: To determine serum level of the protease inhibitor, to identify phenotypes and determine their frequencies.
Study Design: A prospective study.
Setting: PMRC Research Centre, JPMC and the Aga Khan University Hospital Karachi.
Subjects: Healthy aduIts without history ol peptic ulcer disease and a normal endoscopy.
Methodology: Quantitive measurement of serum alpha 1 AT was carried out by radial immunodiffusion. phenotyping by iso-electric focusing and confirmation of phenotypes by immunofixation and DNA analysis technique.
Results:Serum alpha I AT was low in 13.4% of the subjects. Ni MM phenotype predominated followed by SZ SS, MZ and ZZ. DNA diagnosis accurately resolved the phenotypes as S and Z.
Conclusion: Frequency by phenotype associated with total and intermediate deficiency is less in the population
Publication (Name of Journal)
Journal Of Pakistan Medical Association
Recommended Citation
Shahid, A.,
Siddiqui, A.,
Zuberi, S. J.,
Waqar, M.
(2000). Phenotypes of Alpha 1 Antitrypsin in Karachi, Pakistan. Journal Of Pakistan Medical Association.
Available at:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/255