Antibacterial, antifungal, antispasmodic and Ca++ antagonist effects of Caesalpinia bonducella
Biological and Biomedical Sciences
Caesalpinia bonducella F. (Leguminosae) has been used as a folk medicine for a variety of ailments. The crude extract of C. bonducella and its fractions were studied for antibacterial, antifungal, antispasmodic and Ca++ antagonistic properties. The strongest antibacterial effect was displayed by the n-butanol (72%) and ethyl acetate (80%) fractions, followed by the crude extract (46% and 42%), against Escherichia coli and Bacillus subtilis, respectively. The plant extract and its fractions showed mild to excellent activity in antifungal bioassays, with maximum antifungal activity against Candida glaberata (80%) and Aspergillus flavus (70%) by the n-butanol and chloroform fractions, followed by the crude extract (70% and 65%). Caesalpinia bonducella extract caused concentration-dependent inhibition of spontaneous and high K+ (80 mM)-induced contractions of isolated rabbit jejunum preparations, similar to that caused by Verapamil. These results indicate that C. bonducella exhibits antibacterial, antifungal, spasmolytic and Ca++ channel blocking actions.
Natural Products Research
Khanab, H. -.,
Khan, A. -.,
Gilani, A. H.
(2011). Antibacterial, antifungal, antispasmodic and Ca++ antagonist effects of Caesalpinia bonducella. Natural Products Research, 25(4), 444-449.
Available at: http://ecommons.aku.edu/pakistan_fhs_mc_bbs/220