Title

Antifungal and antispasmodic activities of the extracts of Euphorbia granulata

Document Type

Article

Department

Biological and Biomedical Sciences

Abstract

The dichloromethane and methanolic extracts of the plant Euphorbia granulata were investigated for their antifungal, antibacterial, phytotoxic, brine-shrimp cytotoxic, antioxidant, spasmolytic (antispasmodic) and acetylcholinestrase inhibitory activities. The dichloromethane extract showed strong inhibition against Microsporum canis (90%) and against Aspergillus flavus (50%). Both the extracts inhibited the spontaneous contractions in rabbit jejunum preparations with EC50 value of 0.17 and 1.3 mg/mL, respectively and also relaxed the K+-induced contractions with EC50 0.2 and 2.8 mg/mL, respectively, suggesting a calcium channel blocking activity. However, the extracts did not show antibacterial, phytotoxic, brine-shrimp cytotoxic, antioxidant and acetylcholinestrase inhibitory activities.

Publication

Journal of Medicinal Plants Research