Effect of alcohol on the postnatal development of cerebellar cortex in rat II: ultrastructural study
Document Type
Article
Department
Haematology and Oncology, East Africa
Abstract
In The present work, it was found that alcohol produced distinct changes in both Purkinje and granule cells during postnatal development. On the fifth day, the apical cones of the Purkinje cells were less developed and the cells showed an occasional somnatic spines but no somatic processes. At 21 days and adult stage these cells including their dendrites showed marked degenerative changes. The nuinber of basket cell axon synapses on Purkinje cell soma was reduced. There was also a reduction in the amount of basket fibers contributing to the pinceau around the intial seginent of the Purkinje cell axons. The granule cells showed a marked change starting from five days old. These cells decreased in size and lost most of the organelles. Their axons and dendrites as well as mossy fibers were also affected. Signs of glial activation and proliferation were present in the from of formation of myelin sheaths around the degenerated fibers.
Publication (Name of Journal)
Assiut Veterinary Medical Journal
DOI
https://doi.org/10.21608/avmj.1995.184084
Recommended Citation
Saleh, M.,
Sayed, S.,
Saber, E.
(1995). Effect of alcohol on the postnatal development of cerebellar cortex in rat II: ultrastructural study. Assiut Veterinary Medical Journal, 33(65), 18-33.
Available at:
https://ecommons.aku.edu/eastafrica_fhs_mc_haematol_oncol/123
Comments
This work was published before the author joined Aga Khan University.