Event Title

Hypolipidemic effects of Fenugreek (Trigonella foenum-graecum) seed powder against diet induced hyperlipidemia

Location

Auditorium Pond Side

Start Date

26-2-2014 10:30 AM

Abstract

Objective: Cardiovascular diseases (CVD) are the leading cause of death all over the world. Among several other risk factors for coronary artery disease (CAD) the most significant risk factor is dyslipidemia (lipid disorder) which possibly result in atherosclerotic vascular walls. Identification of therapies that will be effective not only against dyslipidemia but also against other risk factors of CVD is important. Non pharmacological therapies are usually considered as the most reliable mode of treatment for primary cases of CVDs and dietary therapies commonly recommend as the first choice of treatment. Present study is designed to investigate the efficacy of one of the most common Indian culinary spice Fenugreek seed (powder) consumption on diet induced hyperlipidemia.

Material & Methods: Total of eighteen, female, white rabbits were used in the study. After one week acclimatization period, animals were administered atherogenic diet for four weeks. 10mg of fenugreek seed powder were fed daily to these hyperlipidemic animals for next 15 days and at the end of experimental period blood specimens were obtained and assayed for alterations in plasma total cholesterol, triglyceride, HDL-C and LDL-C levels.

Results: Results of the present study showed that administration of atherogenic diet increase plasmatic lipid profile in experimental animals. Per day administration of fenugreek seed powder in these animals reduce plasma levels of total cholesterol (P>0.05) and triglyceride (P<0.05). HDL-C and LDL-C levels were also changed but that was a non-significant change. Conclusion: Fenugreek seed powder administration is effective in managing dietary hyperlipidemia in experimental animal models.

Keywords: Fenugreek, Hypolipidemic effects, Dyslipidemia, Rabbits

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Feb 26th, 10:30 AM

Hypolipidemic effects of Fenugreek (Trigonella foenum-graecum) seed powder against diet induced hyperlipidemia

Auditorium Pond Side

Objective: Cardiovascular diseases (CVD) are the leading cause of death all over the world. Among several other risk factors for coronary artery disease (CAD) the most significant risk factor is dyslipidemia (lipid disorder) which possibly result in atherosclerotic vascular walls. Identification of therapies that will be effective not only against dyslipidemia but also against other risk factors of CVD is important. Non pharmacological therapies are usually considered as the most reliable mode of treatment for primary cases of CVDs and dietary therapies commonly recommend as the first choice of treatment. Present study is designed to investigate the efficacy of one of the most common Indian culinary spice Fenugreek seed (powder) consumption on diet induced hyperlipidemia.

Material & Methods: Total of eighteen, female, white rabbits were used in the study. After one week acclimatization period, animals were administered atherogenic diet for four weeks. 10mg of fenugreek seed powder were fed daily to these hyperlipidemic animals for next 15 days and at the end of experimental period blood specimens were obtained and assayed for alterations in plasma total cholesterol, triglyceride, HDL-C and LDL-C levels.

Results: Results of the present study showed that administration of atherogenic diet increase plasmatic lipid profile in experimental animals. Per day administration of fenugreek seed powder in these animals reduce plasma levels of total cholesterol (P>0.05) and triglyceride (P<0.05). HDL-C and LDL-C levels were also changed but that was a non-significant change. Conclusion: Fenugreek seed powder administration is effective in managing dietary hyperlipidemia in experimental animal models.

Keywords: Fenugreek, Hypolipidemic effects, Dyslipidemia, Rabbits