Event Title

Coadministration of buspirone can attenuation apomorphine-induced psychosis: relationship with serotonin and dopamine metabolism in caudate and nucleus accumbens

Location

Auditorium Pond Side

Start Date

26-2-2014 10:30 AM

Abstract

Previously we have monitored the attenuation of apomorphine-induced behavioral sensitization by desensitizing somatodendritic 5-hydroxy tryptamine (5-HT)1A receptors upon repeated administration of buspirone at the dose of 1.0 mg/kg. To monitor the role of repeated administration of buspirone in apomorphine-induced addiction, the present study examines its effect on apomorphine induced conditioned place preference and anxiety. Rats received one (daily; 1.0 mg/kg) injection of apomorphine on alternate days (for 12 days) and apomorphine administration was paired with placement in light compartment of light dark activity box (conditioned place preference; widely used animal model of addiction). Buspirone (1.0 mg/kg) was injected daily and was not paired with any of the two compartments of the apparatus. We tested the hypothesis that desensitization of somatodendritic 5-HT1A receptors upon repeated administration of buspirone, may attenuate apomorphine-induced addictive effects. Administration of apomorphine at a dose of 1.0 mg/kg increased number of entries as well as time spent in the light compartment of the conditioned place preference (CPP) apparatus. Coadministration of buspirone at a dose of 1.0 mg/kg attenuated apomorphine-induced reinforcement. Buspirone at the dose of 1.0 mg/kg did not alter the activity of saline injected animals. Results suggest that buspirone may attenuate apomorphine-induced addiction and could be a useful compound for extending therapeutics of psychostimulants.

Keywords: Apomorphine, reinforcement, buspirone, conditioned place preference

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Feb 26th, 10:30 AM

Coadministration of buspirone can attenuation apomorphine-induced psychosis: relationship with serotonin and dopamine metabolism in caudate and nucleus accumbens

Auditorium Pond Side

Previously we have monitored the attenuation of apomorphine-induced behavioral sensitization by desensitizing somatodendritic 5-hydroxy tryptamine (5-HT)1A receptors upon repeated administration of buspirone at the dose of 1.0 mg/kg. To monitor the role of repeated administration of buspirone in apomorphine-induced addiction, the present study examines its effect on apomorphine induced conditioned place preference and anxiety. Rats received one (daily; 1.0 mg/kg) injection of apomorphine on alternate days (for 12 days) and apomorphine administration was paired with placement in light compartment of light dark activity box (conditioned place preference; widely used animal model of addiction). Buspirone (1.0 mg/kg) was injected daily and was not paired with any of the two compartments of the apparatus. We tested the hypothesis that desensitization of somatodendritic 5-HT1A receptors upon repeated administration of buspirone, may attenuate apomorphine-induced addictive effects. Administration of apomorphine at a dose of 1.0 mg/kg increased number of entries as well as time spent in the light compartment of the conditioned place preference (CPP) apparatus. Coadministration of buspirone at a dose of 1.0 mg/kg attenuated apomorphine-induced reinforcement. Buspirone at the dose of 1.0 mg/kg did not alter the activity of saline injected animals. Results suggest that buspirone may attenuate apomorphine-induced addiction and could be a useful compound for extending therapeutics of psychostimulants.

Keywords: Apomorphine, reinforcement, buspirone, conditioned place preference