Event Title

Sensitivity and specificity of bedside troponin I kit (qualitative) test as compared with the standardized quantitative lab test for troponin I

Location

Auditorium Pond Side

Start Date

26-2-2014 10:30 AM

Abstract

Objective: Our aim was to find out the sensitivity and specificity of (qualitative) troponin I kit against the quantitative lab kit for Troponin I.

Material And Method: Admitted patients of ACS/NSTEMI at Karachi Institute of Heart Diseases of both gender, were administered a standardized questionnaire. Quantitative analysis of Trop I was carried out by the hospital laboratory. At the same time sample was used for qualitative analysis of Troponin I by using Troponin I test kit.

Results: We recruited 50 patients in which 37 (74%) were male. Hypertensive 32 (64%), dyslipidemia in 13 (26%), family history in 15 (30%), DM in 16 (32%) smoking was prevalent in 11 (22%), previous MI in 10 (20%). The kit showed 97% sensitivity and 100% specificity as compared to the quantitative test with a cutoff of 0.30 ng/dl, i.e.; quantitative test showed 32 positive and 18 negative cases, whereas qualitative test shows 31 positive and 19 negative. The difference in test results was on a value of 0.40 ng/dl , as qualitative test showed it as negative result.

Conclusion: Study showed that qualitative kit is highly sensitive and specific at higher values of Troponin I, i.e., ≥ 0.5 ng/dl. The qualitative test could be very beneficial in cost and time saving for the non-conclusive patients, like NSTEMI and ACS in emergency department and patients coming to outreach chest pain centers where laboratory services are not adequate, and whose Trop I values are not very close to the minimum cut off values.

Keywords: Troponin I, specificity, MI

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Feb 26th, 10:30 AM

Sensitivity and specificity of bedside troponin I kit (qualitative) test as compared with the standardized quantitative lab test for troponin I

Auditorium Pond Side

Objective: Our aim was to find out the sensitivity and specificity of (qualitative) troponin I kit against the quantitative lab kit for Troponin I.

Material And Method: Admitted patients of ACS/NSTEMI at Karachi Institute of Heart Diseases of both gender, were administered a standardized questionnaire. Quantitative analysis of Trop I was carried out by the hospital laboratory. At the same time sample was used for qualitative analysis of Troponin I by using Troponin I test kit.

Results: We recruited 50 patients in which 37 (74%) were male. Hypertensive 32 (64%), dyslipidemia in 13 (26%), family history in 15 (30%), DM in 16 (32%) smoking was prevalent in 11 (22%), previous MI in 10 (20%). The kit showed 97% sensitivity and 100% specificity as compared to the quantitative test with a cutoff of 0.30 ng/dl, i.e.; quantitative test showed 32 positive and 18 negative cases, whereas qualitative test shows 31 positive and 19 negative. The difference in test results was on a value of 0.40 ng/dl , as qualitative test showed it as negative result.

Conclusion: Study showed that qualitative kit is highly sensitive and specific at higher values of Troponin I, i.e., ≥ 0.5 ng/dl. The qualitative test could be very beneficial in cost and time saving for the non-conclusive patients, like NSTEMI and ACS in emergency department and patients coming to outreach chest pain centers where laboratory services are not adequate, and whose Trop I values are not very close to the minimum cut off values.

Keywords: Troponin I, specificity, MI