Day 1 : Poster Presentations (Theme: Patient Safety)

Event Title

Renal clearance and urinary excretion of ciprofloxacin in nili/ravi buffalos

Presenter Information

Zahid Iqbal, Isra University

Location

Auditorium Pond Side

Start Date

26-1-2013 10:30 AM

Abstract

Background: Ciprofloxacin belongs to second generation of FQs and exhibits similar properties like other drugs of this class. It is vastly prescribed FQ in veterinary and human health clinics. It is taken as drug of choice in lot of infectious diseases because it is equally effective against gram negative and gram positive bacteria, reflecting its broad spectrum of activity.

Methods: Ciprofloxacin was administered at the rate of 5 mg/kg body weight intramuscularly, to each of eight animals. After administration of drug, blood and urine samples were drawn at various time intervals and concentrations of ciprofloxacin and creatinine were analyzed using high performance

liquid chromatography (HPLC) and creatinine kits, respectively.

Results: The renal clearance of endogenous creatinine was recorded to be 0.722 ± 0.148 ml/min/kg and that of ciprofloxacin was 0.469 ± 0.06 ml/min/kg. The ratio between renal clearances of ciprofloxacin and creatinine remained less than one. Ciprofloxacin excreted into the urine of buffalos during 10 hours, as cumulative percentage of intramuscular dose administered, was 10.04 ± 1.17 percent. Conclusions: Based on these results, we concluded that, in local buffalos, active tubular secretion and back diffusion were also involved in renal handling of ciprofloxacin along with glomerular filtration.

Keywords: Ciprofloxacin, Renal clearance, Urinary excretion, Nili/Ravi buffalos

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Jan 26th, 10:30 AM Jan 26th, 12:00 PM

Renal clearance and urinary excretion of ciprofloxacin in nili/ravi buffalos

Auditorium Pond Side

Background: Ciprofloxacin belongs to second generation of FQs and exhibits similar properties like other drugs of this class. It is vastly prescribed FQ in veterinary and human health clinics. It is taken as drug of choice in lot of infectious diseases because it is equally effective against gram negative and gram positive bacteria, reflecting its broad spectrum of activity.

Methods: Ciprofloxacin was administered at the rate of 5 mg/kg body weight intramuscularly, to each of eight animals. After administration of drug, blood and urine samples were drawn at various time intervals and concentrations of ciprofloxacin and creatinine were analyzed using high performance

liquid chromatography (HPLC) and creatinine kits, respectively.

Results: The renal clearance of endogenous creatinine was recorded to be 0.722 ± 0.148 ml/min/kg and that of ciprofloxacin was 0.469 ± 0.06 ml/min/kg. The ratio between renal clearances of ciprofloxacin and creatinine remained less than one. Ciprofloxacin excreted into the urine of buffalos during 10 hours, as cumulative percentage of intramuscular dose administered, was 10.04 ± 1.17 percent. Conclusions: Based on these results, we concluded that, in local buffalos, active tubular secretion and back diffusion were also involved in renal handling of ciprofloxacin along with glomerular filtration.

Keywords: Ciprofloxacin, Renal clearance, Urinary excretion, Nili/Ravi buffalos